General info about the project

Objectives

• The project aims to test two clinically relevant hypotheses: After sustaining traumatic brain injury (TBI), paediatric patients with a longer period of measured cerebral perfusion pressure (CPP) maintained within the calculated optimal CPP (CPPopt) range have (1) an improved global clinical outcome, and (2) better tolerance against raised intracranial pressure (ICP).
• To achieve this aim, we are developing a new multi-centre, multidisciplinary, and multinational Paediatric Brain Monitoring and Information Technology Group (KidsBrainIT), which includes a central data repository to store prospectively collected minute-resolution physiological, clinical, and outcome data. This infrastructure allows analyses on sub-sets of the data to apply novel data models and calculate validated indices as metrics of clinical management quality that are fed back to clinicians working within units contributing to KidsBrainIT. Developing this type of infrastructure is essential for investigations on how feedback of clinical management quality indices can influence and improve future treatment in later phases of KidsBrainIT. Data from the KidsBrainIT central data-bank are used to test our hypotheses.

Estimated results

1. Improvement of paediatric TBI intensive care management in the UK, Europe, North America and beyond
2. Validated results: ICP dose-response graphs for three clinically relevant agebands are readily translated back to clinical practice to allow a more refined evidence based management of raised ICP
3. Journal and conference presentations
4. Therapeutical guide.